主要應(yīng)用
The main application
Liposome doxorubicin
Amphotericin B liposome
Paclitaxel liposomes
Oxaliplatin liposomes
Irinotecan liposome
SiRNA liposome
Albumin paclitaxel nanoparticles
Nucleic acid liposome
Other whole li posome samples
擠出原理
Technical features
脂質(zhì)體擠出的原理在于，通過(guò)一定的擠出動(dòng)力源將脂質(zhì)體樣品粒子進(jìn)行擠壓，使其在一定壓力條件下通過(guò) PC濾膜， 此壓力作為粒子過(guò)膜過(guò)程中的剪切力可使其達(dá)到粒徑控制的效果。不論形態(tài)、大小和分布都可得到極大改善。
The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.
支撐板和濾板主要起到支撐濾膜的作用。 由于磷脂有一定的相變溫度，所以在擠出之前需要對(duì)擠出器夾套通入恒溫水進(jìn)行預(yù)熱至一定溫度（50~60℃），且在使用過(guò)程中需保持在此溫度。通常的脂質(zhì)體品種擠出之后粒徑能達(dá)到 100nm以下，PDI 能控制在 0.1 以下。
The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.
動(dòng)力源：氮?dú)?/p>
Power source: nitrogen
技術(shù)特征
Technical features
核心部件 The core components
Support plate (SS316L stainless steel)
Filter plate (SS316L stainless steel)
Filter membrane :PC material (polycarbonate)
Sealing system: PU material/polytetrafluoroethylene
Temperature control system: jacket control warm water
技術(shù)特點(diǎn) Technical characteristics
Low sample consumption
High extrusion pressure
No residue
No manual operation required
Whole process temperature control
All parts including "O" rings, gaskets are FDA approved
Easy loading and unloading, easy cleaning and sterilization
All data can be directly amplified
Can be used for high concentration sample processing
Can be used in a clean room, in line with GMP standards
技術(shù)參數(shù)
Technical Parameter
| 型號(hào) MODEL | Extru 25-20 |
|
最高壓力 [Mpa] The highest pressure[Mpa] |
25 |
|
最終產(chǎn)品粒徑 [nm] Final product size [nm] |
50~1000 |
|
單批處理量[ml] The Final product size[ml] |
0~20 |
|
最高產(chǎn)品濃度[mg/ml] Maximum product concentration[mg/ml] |
200 |
|
工作溫度范圍 Operating temperature range |
5~80℃ |
|
產(chǎn)品材質(zhì) Product material |
SS316L |
|
直徑[mm] The diameter of[mm] |
25 |
| 動(dòng)力源類(lèi)型 Power source type |
Gas |
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