Hot sell Trimethoprim/TMP/38-70-5
1.Cas No.:38-70-5
2.Color:white
3.Standard:CP/USP
4.Packing:25kg/drum
Hot sell Trimethoprim/TMP/38-70-5
1.Cas No.:38-70-5
2.Color:white
3.Standard:CP/USP
4.Packing:25kg/drum
Trimethoprim/TMP/CAS NO.:38-70-5
1.CAS NO.:38-70-5
2.Color:White powder
3.Standard:CP/USP
4.Packing:25kg/drum
Trimethoprim (INN) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Trimethoprim was formerly marketed by GlaxoSmithKline under trade names including Proloprim, Monotrim and Triprim; but these trade names have been licensed to various generic pharmaceutical manufacturers. In clinical use it is often abbreviated TRI or TMP; its common laboratory abbreviation is W.
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Items |
Standard |
Results |
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Appearance |
White or yellowish-white powder |
White powder |
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Solubility |
Very slightly soluble in water, slightly soluble in alcohol. |
Very slightly soluble in water, slightly soluble in alcohol. |
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•Identification |
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A: Melting point |
199-203 |
201.0-201.4 |
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B: Specific absorbance |
Max.287nm: 240-250 |
243 |
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C: IR-spectrum |
Complies with reference spectrum |
Complies with reference spectrum |
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D: Chemical reaction |
Green fluorescence at 365nm |
Green fluorescence at 365nm |
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Appearance of solution |
Not more intensely colored than Reference Solution BY7 |
Less intensely colored than reference solution BY7 |
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Related substances |
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Method A by HPLC: |
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Impurity F |
≤0.1% |
0.05% |
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Any single impurity |
≤0.1% |
<0.1% |
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Total impurities |
≤0.2% |
<0.2% |
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Method B by HPLC: |
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Any single impurity |
≤0.1% |
<0.1% |
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Total impurities |
≤0.2% |
<0.2% |
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Heavy metals |
≤20ppm |
< 20ppm |
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Residual methanol |
≤3000ppm |
Not detected |
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Residual DMSO |
≤5000ppm |
Not detected |
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Residual acetic acid |
≤5000ppm |
Not detected |
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Impurity K(aniline) by GC |
≤5ppm |
Not detected |
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Loss on drying |
≤0.5% |
0.3% |
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Sulphated ash |
≤0.1% |
0.02% |
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Assay |
98.5-101.0% |
99.71% |
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Particle size |
100% pass 300 mesh |
100% pass 300 mesh |
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